Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

BACKGROUND: Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant. METHODS: We whole-genome sequenced M....

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Détails bibliographiques
Publié dans:BMC Genomics
Auteurs principaux: Ruesen, Carolien, Chaidir, Lidya, van Laarhoven, Arjan, Dian, Sofiati, Ganiem, Ahmad Rizal, Nebenzahl-Guimaraes, Hanna, Huynen, Martijn A., Alisjahbana, Bachti, Dutilh, Bas E., van Crevel, Reinout
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800017/
https://ncbi.nlm.nih.gov/pubmed/29402222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4498-z
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