Automated Coupling of Nanodroplet Sample Preparation with Liquid Chromatography-Mass Spectrometry for High-Throughput Single-Cell Proteomics

Single-cell proteomics can provide critical biological insight into the cellular heterogeneity that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet processing in one pot for trace samples) platform and demonstrated its broad applicability for single-cell proteomics. Howev...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Williams, Sarah M., Liyu, Andrey V., Tsai, Chia-Feng, Moore, Ronald J., Orton, Daniel J., Chrisler, William B., Gaffrey, Matthew J., Liu, Tao, Smith, Richard D., Kelly, Ryan T., Pasa-Tolic, Ljiljana, Zhu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793572/
https://ncbi.nlm.nih.gov/pubmed/32639140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01551
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