Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5–13.5 due to severe hemorrhage. Here, conditional del...

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Publicado en:PLoS Genet
Main Authors: Robledo, Raymond F., Ciciotte, Steven L., Graber, Joel H., Zhao, Yue, Lambert, Amy J., Gwynn, Babette, Maki, Nathaniel J., Brindley, Elena C., Hartman, Emily, Blanc, Lionel, Peters, Luanne L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793307/
https://ncbi.nlm.nih.gov/pubmed/33370780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008857
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