Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5–13.5 due to severe hemorrhage. Here, conditional del...

詳細記述

保存先:
書誌詳細
出版年:PLoS Genet
主要な著者: Robledo, Raymond F., Ciciotte, Steven L., Graber, Joel H., Zhao, Yue, Lambert, Amy J., Gwynn, Babette, Maki, Nathaniel J., Brindley, Elena C., Hartman, Emily, Blanc, Lionel, Peters, Luanne L.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793307/
https://ncbi.nlm.nih.gov/pubmed/33370780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008857
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