Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

HIV-1 envelope (Env) is a trimer of gp120-gp41 heterodimers, synthesized from a precursor gp160 that contains an ER-targeting signal peptide (SP) at its amino-terminus. Each trimer is swathed by ~90 N-linked glycans, comprising complex-type and oligomannose-type glycans, which play an important role...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Upadhyay, Chitra, Feyznezhad, Roya, Cao, Liwei, Chan, Kun-Wei, Liu, Kevin, Yang, Weiming, Zhang, Hui, Yolitz, Jason, Arthos, James, Nadas, Arthur, Kong, Xiang-Peng, Zolla-Pazner, Susan, Hioe, Catarina E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793277/
https://ncbi.nlm.nih.gov/pubmed/33370382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009185
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