Llwytho...

The p53 inactivators pifithrin-μ and pifithrin-α mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy

Traumatic brain injury (TBI) is one of the most common causes of death and disability worldwide. We investigated whether inhibition of p53 using pifithrin (PFT)-α or PFT-μ provides neuroprotective effects via p53 transcriptional dependent or -independent mechanisms, respectively. Sprague Dawley rats...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Neurol
Prif Awduron: Yang, Ling-Yu, Greig, Nigel H., Tweedie, David, Jung, Yoo Jin, Chiang, Yung-Hsiao, Hoffer, Barry J., Miller, Jonathan P., Chang, Ke-Hui, Wang, Jia-Yi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792017/
https://ncbi.nlm.nih.gov/pubmed/31778663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113135
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