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Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly
A major challenge to long read sequencing data is their high error rate of up to 15%. We present Ratatosk, a method to correct long reads with short read data. We demonstrate on 5 human genome trios that Ratatosk reduces the error rate of long reads 6-fold on average with a median error rate as low...
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| Publié dans: | Genome Biol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7792008/ https://ncbi.nlm.nih.gov/pubmed/33419473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02244-4 |
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