PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

BACKGROUND: The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their activity. Recently, PD-1 expression has also been found in can...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Liotti, Federica, Kumar, Narender, Prevete, Nella, Marotta, Maria, Sorriento, Daniela, Ieranò, Caterina, Ronchi, Andrea, Marino, Federica Zito, Moretti, Sonia, Colella, Renato, Puxeddu, Efiso, Paladino, Simona, Kano, Yoshihito, Ohh, Michael, Scala, Stefania, Melillo, Rosa Marina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791757/
https://ncbi.nlm.nih.gov/pubmed/33413561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01818-1
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