Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

BACKGROUND: As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be attributed to increasing cell densities within bioreactors. As such,...

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Detaylı Bibliyografya
Yayımlandı:BMC Biotechnol
Asıl Yazarlar: Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791692/
https://ncbi.nlm.nih.gov/pubmed/33419422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00667-2
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