Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFβR1/Smad2/3 pathway

BACKGROUND: Lower back pain is often accredited to loss of intervertebral disc (IVD) height and compromised spine stability as a result of intervertebral disc degeneration (IVDD). We aim to locally use bleomycin to induce the fibrotic transformation of bone marrow stromal cells (BMSCs) as a means to...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Yang, Xiao, Chen, Zhiqian, Chen, Chen, Han, Chen, Zhou, Yifan, Li, Xunlin, Tian, Haijun, Cheng, Xiaofei, Zhang, Kai, Qin, An, Zhou, Tangjun, Zhao, Jie
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791639/
https://ncbi.nlm.nih.gov/pubmed/33413668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02093-9
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