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L51P, a novel mutation in the PAS domain of hERG channel, confers long QT syndrome by impairing channel activation

The human ether-à-go-go-related gene (hERG) potassium channel mediates the repolarization of ventricular action potentials. Mutations in the KCNH2 cause long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. Here, we functionally analyzed a mutation of hERG potassium c...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Wang, Mi, Gao, Min, Fang, Senbiao, Zheng, Ruoqian, Peng, Daoquan, Luo, Qin, Yu, Bilian
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791479/
https://ncbi.nlm.nih.gov/pubmed/33437379
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