Relocation of an extrasynaptic GABA(A) receptor to inhibitory synapses freezes excitatory synaptic strength and preserves memory

The excitatory synapse between hippocampal CA3 and CA1 pyramidal neurons exhibits long-term potentiation (LTP), a positive feedback process implicated in learning and memory, in which postsynaptic depolarization strengthens synapses, promoting further depolarization. Without mechanisms for interrupt...

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Veröffentlicht in:Neuron
Hauptverfasser: Davenport, Christopher M., Rajappa, Rajit, Katchan, Ljudmila, Taylor, Charlotte R., Tsai, Ming-Chi, Smith, Caleb M., de Jong, Johannes, Arnold, Don B., Lammel, Stephan, Kramer, Richard H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790995/
https://ncbi.nlm.nih.gov/pubmed/33096025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.09.037
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