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CRISPR/Cas9-loaded stealth liposomes effectively cleared established HPV16-driven tumours in syngeneic mice

Gene-editing has raised the possibility of being able to treat or cure cancers, but key challenges remain, including efficient delivery, in vivo efficacy, and its safety profile. Ideal targets for cancer therapy are oncogenes, that when edited, cause cell death. Here, we show, using the human papill...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jubair, Luqman, Lam, Alfred K., Fallaha, Sora, McMillan, Nigel A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790238/
https://ncbi.nlm.nih.gov/pubmed/33411765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223288
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