Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk

BACKGROUND: Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment. METHODS: We perfo...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Am Soc Nephrol
Main Authors: Rudman-Melnick, Valeria, Adam, Mike, Potter, Andrew, Chokshi, Saagar M., Ma, Qing, Drake, Keri A., Schuh, Meredith P., Kofron, J. Matthew, Devarajan, Prasad, Potter, S. Steven
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Nephrology 2020
נושאים:
Basic Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790221/
https://ncbi.nlm.nih.gov/pubmed/33115917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020010052
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