Single-Nucleus RNA-Sequencing Profiling of Mouse Lung. Reduced Dissociation Bias and Improved Rare Cell-Type Detection Compared with Single-Cell RNA Sequencing

Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell types by death or inadequate dissociation, and transcriptional stress responses induced during tissue digestion. Single-nucleus RNA sequencing...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Main Authors: Koenitzer, Jeffrey R., Wu, Haojia, Atkinson, Jeffrey J., Brody, Steven L., Humphreys, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2020
Assuntos:
Major Technical Advances
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790136/
https://ncbi.nlm.nih.gov/pubmed/32804550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0095MA
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