Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury

To investigate T helper type 17 (Th17) cells in the setting of acute kidney injury, the gene encoding the master regulator of Th17 cell differentiation, that is, RAR-related orphan receptor-γ (RORγT), was mutated in Lewis rats using CRISPR/Cas9 technology. In response to 40 min of bilateral renal is...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Mehrotra, Purvi, Ullah, Md Mahbub, Collett, Jason A., Myers, Sarah L., Dwinell, Melinda R., Geurts, Aron M., Basile, David P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789982/
https://ncbi.nlm.nih.gov/pubmed/32924545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00187.2020
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