Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury

Multiple clinical and preclinical studies have demonstrated that plasma levels of asymmetric dimethylarginine (ADMA) are strongly associated with hypertension, diabetes, and cardiovascular and renal disease. Genetic studies in rodents have provided evidence that ADMA metabolizing dimethylarginine di...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Lee, Young, Mehrotra, Purvi, Basile, David, Ullah, Mahbub, Singh, Arshnoor, Skill, Nicholas, Younes, Subhi Talal, Sasser, Jennifer, Shekhar, Anantha, Singh, Jaipal
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2021
Предметы:
Cardiovascular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816763/
https://ncbi.nlm.nih.gov/pubmed/33214214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000212
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