Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells

BACKGROUND: Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are overexpr...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Shi, Yu, Sun, Liankang, Zhang, Rui, Hu, Yuan, Wu, Yinying, Dong, Xuyuan, Dong, Danfeng, Chen, Chen, Geng, Zhimin, Li, Enxiao, Fan, Yangwei
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789630/
https://ncbi.nlm.nih.gov/pubmed/33407730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01812-7
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