Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Moreover, RUPP and PE women have elevated vasoconstrictor peptide endothelin-1 (ET-1) and inf...

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Veröffentlicht in:Biol Sex Differ
Hauptverfasser: Cunningham, Mark W., Amaral, Lorena M., Campbell, Nathan E., Cornelius, Denise C., Ibrahim, Tarek, Vaka, Venkata Ramana, LaMarca, Babbette
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789596/
https://ncbi.nlm.nih.gov/pubmed/33407826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-020-00345-0
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