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Connecting the αα-hubs: same fold, disordered ligands, new functions
BACKGROUND: Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-helical domains of large, modular proteins binding intrinsically disordered trans...
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| Veröffentlicht in: | Cell Commun Signal |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7788954/ https://ncbi.nlm.nih.gov/pubmed/33407551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00686-8 |
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