Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates

[Image: see text] (R)-[(11)C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood–brain barrier (BBB). Several studies have evaluated the pharmacokinetics of (R)-[(11)C]verapamil in rats and humans under different conditions. However, to the be...

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Publicado no:Mol Pharm
Main Authors: García-Varela, Lara, García, David Vállez, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H., Tsukada, Hideo, Colabufo, Nicola A., Dierckx, Rudi A.J.O., van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788571/
https://ncbi.nlm.nih.gov/pubmed/33315404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c01014
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