Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance

BACKGROUND & AIMS: Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell–CAF interactions. Here, we aimed to establish 3-dimensional (3D)...

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Publicat a:Cell Mol Gastroenterol Hepatol
Autors principals: Liu, Jiaye, Li, Pengfei, Wang, Ling, Li, Meng, Ge, Zhouhong, Noordam, Lisanne, Lieshout, Ruby, Verstegen, Monique M.A., Ma, Buyun, Su, Junhong, Yang, Qin, Zhang, Ruyi, Zhou, Guoying, Carrascosa, Lucia Campos, Sprengers, Dave, IJzermans, Jan N.M., Smits, Ron, Kwekkeboom, Jaap, van der Laan, Luc J.W., Peppelenbosch, Maikel P., Pan, Qiuwei, Cao, Wanlu
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788239/
https://ncbi.nlm.nih.gov/pubmed/32932015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.09.003
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