LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C>T variant in the lysophosphatidylinositol acyltransferase 1 (LPIAT1)/membrane bound O-acyltransferase domain-containing 7, which incorporates arachidonic acid...

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Bibliografiske detaljer
Udgivet i:Gut
Main Authors: Tanaka, Yuki, Shimanaka, Yuta, Caddeo, Andrea, Kubo, Takuya, Mao, Yanli, Kubota, Tetsuya, Kubota, Naoto, Yamauchi, Toshimasa, Mancina, Rosellina Margherita, Baselli, Guido, Luukkonen, Panu, Pihlajamäki, Jussi, Yki-Järvinen, Hannele, Valenti, Luca, Arai, Hiroyuki, Romeo, Stefano, Kono, Nozomu
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2021
Fag:
Hepatology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788230/
https://ncbi.nlm.nih.gov/pubmed/32253259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2020-320646
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