Experimental and bioinformatics considerations in cancer application of single cell genomics

Single cell genomics offers an unprecedented resolution to interrogate genetic heterogeneity in a patient’s tumour at the intercellular level. However, the DNA yield per cell is insufficient for today’s sequencing library preparation protocols. This necessitates DNA amplification which is a key sour...

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Veröffentlicht in:Comput Struct Biotechnol J
Hauptverfasser: Tan, Joanna Hui Juan, Kong, Say Li, Tai, Joyce A., Poh, Huay Mei, Yao, Fei, Sia, Yee Yen, Lim, Edwin Kok Hao, Takano, Angela Maria, Tan, Daniel Shao-Weng, Javed, Asif, Hillmer, Axel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788095/
https://ncbi.nlm.nih.gov/pubmed/33489004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.12.021
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