Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

We demonstrate how RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and thereby determine nematode sex. FOX-1, an RNA recognition motif protein, triggers hermaphrodite development in XX embryos by causing non-productive alternative pre-mRNA...

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Publicat a:eLife
Autors principals: Farboud, Behnom, Novak, Catherine S, Nicoll, Monique, Quiogue, Alyssa, Meyer, Barbara J
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Chromosomes and Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787662/
https://ncbi.nlm.nih.gov/pubmed/33372658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62963
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