Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia

l-DOPA treatment for Parkinson’s disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its...

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Udgivet i:Sci Adv
Main Authors: Fridjonsdottir, Elva, Shariatgorji, Reza, Nilsson, Anna, Vallianatou, Theodosia, Odell, Luke R., Schembri, Luke S., Svenningsson, Per, Fernagut, Pierre-Olivier, Crossman, Alan R., Bezard, Erwan, Andrén, Per E.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787486/
https://ncbi.nlm.nih.gov/pubmed/33523980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5948
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