Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Microglia-mediated neuroinflammation has been implicated in the pathogenesis of Alzheimer’s disease (AD). Although microglia in aging and neurodegenerative disease model mice show a loss of homeostatic phenotype and activation of disease-associated microglia (DAM), a correlation between those phenot...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Sobue, Akira, Komine, Okiru, Hara, Yuichiro, Endo, Fumito, Mizoguchi, Hiroyuki, Watanabe, Seiji, Murayama, Shigeo, Saito, Takashi, Saido, Takaomi C., Sahara, Naruhiko, Higuchi, Makoto, Ogi, Tomoo, Yamanaka, Koji
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786928/
https://ncbi.nlm.nih.gov/pubmed/33402227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01099-x
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