Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (Aβ) and neurofibrillary tangles that usually begins 15–30 years before clinical diagnosis. Rodent models that recapitulate aggressive Aβ and/or the patholog...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Saifullah, Md. Ali Bin, Komine, Okiru, Dong, Yutao, Fukumoto, Kazuya, Sobue, Akira, Endo, Fumito, Saito, Takashi, Saido, Takaomi C., Yamanaka, Koji, Mizoguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664057/
https://ncbi.nlm.nih.gov/pubmed/33183323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00690-6
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