Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood. MyD88- and IRAK4-deficient patients are exceedingly susceptible to a narrow spectrum of pathogens, with ∼50% lethality in the first years of...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Craig-Mueller, Nils, Hammad, Ruba, Elling, Roland, Alzubi, Jamal, Timm, Barbara, Kolter, Julia, Knelangen, Nele, Bednarski, Christien, Gläser, Birgitta, Ammann, Sandra, Ivics, Zoltán, Fischer, Judith, Speckmann, Carsten, Schwarz, Klaus, Lachmann, Nico, Ehl, Stephan, Moritz, Thomas, Henneke, Philipp, Cathomen, Toni
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786022/
https://ncbi.nlm.nih.gov/pubmed/33424861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.608802
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