Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern. Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib sensitivity in TNBC. Gefitinib resistant TNBC...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Song, Xiang, Wang, Xinzhao, Liu, Zhaoyun, Yu, Zhiyong
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785974/
https://ncbi.nlm.nih.gov/pubmed/33425751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.597434
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