Biased Influences of Low Tumor Purity on Mutation Detection in Cancer

The non-cancerous components in tumor tissues, e.g., infiltrating stromal cells and immune cells, dilute tumor purity and might confound genomic mutation profile analyses and the identification of pathological biomarkers. It is necessary to systematically evaluate the influence of tumor purity. Here...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Cheng, Jun, He, Jun, Wang, Shanshan, Zhao, Zhangxiang, Yan, Haidan, Guan, Qingzhou, Li, Jing, Guo, Zheng, Ao, Lu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Molecular Biosciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785586/
https://ncbi.nlm.nih.gov/pubmed/33425983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.533196
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