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Mechanisms associated with the antidepressant-like effects of L-655,708

Previous research has demonstrated that selective modulation of hippocampal transmission by systemic administration of an α5-GABA(A) receptor negative allosteric modulator, L-655,708, reproduces the sustained antidepressant-like (AD-like) effect of R,S-ketamine in the absence of any psychotomimetic...

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Publicado en:Neuropsychopharmacology
Autores principales: Bugay, Vladislav, McCoy, Alexandra Maxine, Lodge, Daniel James, Brenner, Robert, Frazer, Alan, Carreno, Flavia Regina
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785005/
https://ncbi.nlm.nih.gov/pubmed/32688367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-0772-2
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