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Substitutions at Nonconserved Rheostat Positions Modulate Function by Rewiring Long-Range, Dynamic Interactions
Amino acid substitutions at nonconserved protein positions can have noncanonical and “long-distance” outcomes on protein function. Such outcomes might arise from changes in the internal protein communication network, which is often accompanied by changes in structural flexibility. To test this, we c...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Biol Evol |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7783170/ https://ncbi.nlm.nih.gov/pubmed/32780837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa202 |
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