Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia

Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous leukemia (CML). Here, we show that ubiquitin-specific peptidase 47 (USP47) is a potential target to overcome...

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Publicat a:Nat Commun
Autors principals: Lei, Hu, Xu, Han-Zhang, Shan, Hui-Zhuang, Liu, Meng, Lu, Ying, Fang, Zhi-Xiao, Jin, Jin, Jing, Bo, Xiao, Xin-Hua, Gao, Shen-Meng, Gao, Feng-Hou, Xia, Li, Yang, Li, Liu, Li-Gen, Wang, Wei-Wei, Liu, Chuan-Xu, Tong, Yin, Wu, Yun-Zhao, Zheng, Jun-Ke, Chen, Guo-Qiang, Zhou, Li, Wu, Ying-Li
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782553/
https://ncbi.nlm.nih.gov/pubmed/33397955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20259-0
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