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Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway
Chimeric antigen receptor T (CAR-T) cell therapy has been applied successfully in treating hematologic malignancies; however, it shows very limited efficacy in treating solid tumors. Adenosine is one of the key immunosuppressive metabolites in tumor microenvironment (TME) of solid tumors. Although t...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781731/ https://ncbi.nlm.nih.gov/pubmed/33457103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1824643 |
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