Autophosphorylation-induced self-assembly and STIL-dependent reinforcement underlie Plk4’s ring-to-dot localization conversion around a human centriole

Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis. Studies have shown that Plk4 undergoes dynamic relocalization from a ring-like pattern around a centriole to a dot-like morphology at the procentriole assembly site and this event is central for inducing centriole biogenesis. Howe...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Park, Jung-Eun, Meng, Lingjun, Ryu, Eun Kyoung, Nagashima, Kunio, Baxa, Ulrich, Bang, Jeong Kyu, Lee, Kyung S.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781628/
https://ncbi.nlm.nih.gov/pubmed/33323015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1843772
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