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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, due to close similarity with the natural receptor, hold out the promise of bein...
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| Publicado en: | bioRxiv |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781310/ https://ncbi.nlm.nih.gov/pubmed/33398275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.18.344622 |
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