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Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis
IL-7 is essential for T-cell survival but its availability is limited in vivo. Consequently, all peripheral T cells, including recent thymic emigrants (RTEs) are constantly competing for IL-7 to survive. RTEs are required to replenish TCR diversity and rejuvenate the peripheral T-cell pool. However,...
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| Udgivet i: | Eur J Immunol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7780244/ https://ncbi.nlm.nih.gov/pubmed/27129922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546214 |
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