Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics

PURPOSE: Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annot...

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Publicat a:Cardiovasc Drugs Ther
Autors principals: Morales-Rosado, Joel A., Goel, Kashish, Zhang, Lingxin, Åkerblom, Axel, Baheti, Saurabh, Black, John L., Eriksson, Niclas, Wallentin, Lars, James, Stefan, Storey, Robert F., Goodman, Shaun G., Jenkins, Gregory D., Eckloff, Bruce W., Bielinski, Suzette J., Sicotte, Hugues, Johnson, Stephen, Roger, Veronique L., Wang, Liewei, Weinshilboum, Richard, Klee, Eric W., Rihal, Charanjit S., Pereira, Naveen L.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779664/
https://ncbi.nlm.nih.gov/pubmed/32623598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-020-06988-w
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