EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells

Background: Ovarian cancer is a fatal malignant gynecological tumor. Ovarian cancer stem cells (OCSCs) contribute to resistance to chemotherapy. The polycomb group protein enhancer of zeste homolog 2 (EZH2) plays a key role in maintaining CSCs. Here, we aimed to investigate the specific mechanism by...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Theranostics
Main Authors: Wen, Yiping, Hou, Yaya, Yi, Xiaoqing, Sun, Si, Guo, Jing, He, Xiaoqi, Li, Tao, Cai, Jing, Wang, Zehua
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2021
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778604/
https://ncbi.nlm.nih.gov/pubmed/33408782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48101
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