EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion

Enhancer of zeste homolog 2 (EZH2) is often increased in malignant tumors and is involved in metastasis. EZH2 silences gene expression by tri-methylating the lysine 27 residue of histone H3 (H3K27me3). However, the mechanism underlying EZH2 promotion of ovarian cancer metastasis remains elusive. Her...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Yi, Xiaoqing, Guo, Jianfeng, Guo, Jing, Sun, Si, Yang, Ping, Wang, Junjie, Li, Yuan, Xie, Lisha, Cai, Jing, Wang, Zehua
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472630/
https://ncbi.nlm.nih.gov/pubmed/28620234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03362-z
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