Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase domain-like protein (MLKL). Upon activation, MLKL oligomerizes and integrates into the plasma membrane via its execution...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rübbelke, Martin, Fiegen, Dennis, Bauer, Margit, Binder, Florian, Hamilton, James, King, Jim, Thamm, Sven, Nar, Herbert, Zeeb, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7777204/
https://ncbi.nlm.nih.gov/pubmed/33318170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017406117
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