1249. Genetic Evidence That Gepotidacin Shows Well-balanced Dual Targeting against DNA Gyrase And Topoisomerase IV in Neisseria gonorrhoeae

BACKGROUND: Gepotidacin (GEP) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor targeting both bacterial DNA gyrase and topoisomerase IV by a different mechanism from fluoroquinolone antibiotics. Although in vitro frequency of resistance to GEP in Neisseria gonorrhoeae (NG) i...

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發表在:Open Forum Infect Dis
Main Authors: Chan, Pan, Ingraham, Karen, Min, Sharon, Scangarella-Oman, Nicole, Rittenhouse, Steve, Huang, Jianzhong
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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Poster Abstracts
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776390/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofaa439.1433
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