Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the extracellular domain of GPIbα...

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Publicat a:Haematologica
Autors principals: Wang, Yingchun, Chen, Wenchun, Zhang, Wei, Lee-Sundlov, Melissa M., Casari, Caterina, Berndt, Michael C., Lanza, Francois, Bergmeier, Wolfgang, Hoffmeister, Karin M., Zhang, X. Frank, Li, Renhao
Format: Artigo
Idioma:Inglês
Publicat: Fondazione Ferrata Storti 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776245/
https://ncbi.nlm.nih.gov/pubmed/31974202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.240440
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