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Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the extracellular domain of GPIbα...
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| 出版年: | Haematologica |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Fondazione Ferrata Storti
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7776245/ https://ncbi.nlm.nih.gov/pubmed/31974202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.240440 |
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