Case Report: Efficacy of Reduced Doses of Asfotase Alfa Replacement Therapy in an Infant With Hypophosphatasia Who Lacked Severe Clinical Symptoms

BACKGROUND: Hypophosphatasia is a rare bone disease characterized by impaired bone mineralization and low alkaline phosphatase activity. Here, we describe the course of bone-targeted enzyme replacement therapy with asfotase alpha for a female infant patient with hypophosphatasia who lacked apparent...

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Bibliographic Details
Published in:Front Endocrinol (Lausanne)
Main Authors: Fujisawa, Yasuko, Kitaoka, Taichi, Ono, Hiroyuki, Nakashima, Shinichi, Ozono, Keiichi, Ogata, Tsutomu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775725/
https://ncbi.nlm.nih.gov/pubmed/33391183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.590455
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