Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments

Bictegravir (BIC) and tenofovir alafenamide fumarate (TAF), two potent anti-HIV drugs, had been nanoformulated (nBIC-TAF) to achieve once-a-month PrEP coverage. In-vivo mouse experiments for nBIC-TAF exhibited favorable subcutaneous (SC) pharmacokinetics. To probe the clinical suitability of the nBI...

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發表在:Front Pharmacol
Main Authors: Perazzolo, Simone, Mandal, Subhra, Prathipati, Pavan K., Destache, Christopher J.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775496/
https://ncbi.nlm.nih.gov/pubmed/33390993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.603242
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