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Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments

Bictegravir (BIC) and tenofovir alafenamide fumarate (TAF), two potent anti-HIV drugs, had been nanoformulated (nBIC-TAF) to achieve once-a-month PrEP coverage. In-vivo mouse experiments for nBIC-TAF exhibited favorable subcutaneous (SC) pharmacokinetics. To probe the clinical suitability of the nBI...

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Опубликовано в: :Front Pharmacol
Главные авторы: Perazzolo, Simone, Mandal, Subhra, Prathipati, Pavan K., Destache, Christopher J.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775496/
https://ncbi.nlm.nih.gov/pubmed/33390993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.603242
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