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Negative feedback by conserved kinases patterns the degradation of Caenorhabditis elegans Raf in vulval fate patterning

Activation of a canonical EGFR-Ras-Raf-ERK cascade initiates patterning of multipotent vulval precursor cells (VPCs) of Caenorhabditis elegans. We have previously shown that this pathway includes a negative-feedback component in which MPK-1/ERK activity targets the upstream kinase LIN-45/Raf for deg...

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Pubblicato in:Development
Autori principali: de la Cova, Claire C., Townley, Robert, Greenwald, Iva
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774884/
https://ncbi.nlm.nih.gov/pubmed/33144396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.195941
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