Disrupting polycystin-2 EF hand Ca(2+) affinity does not alter channel function or contribute to polycystic kidney disease

Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. Elevated internal Ca(2+) modulates polycystin-2 vol...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Sci
Egile Nagusiak: Vien, Thuy N., Ng, Leo C. T., Smith, Jessica M., Dong, Ke, Krappitz, Matteus, Gainullin, Vladimir G., Fedeles, Sorin, Harris, Peter C., Somlo, Stefan, DeCaen, Paul G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774883/
https://ncbi.nlm.nih.gov/pubmed/33199522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.255562
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak